Broccoli could stop breast cancer spreading by targeting stem cells

Broccoli contains sulforaphane, which seemed to kill off cancer  stem cells in tests

Broccoli contains sulforaphane, which seemed to kill off cancer stem cells in tests

Broccoli could hold the key to preventing and even treating breast cancer, claim scientists.

A chemical found in the vegetable superfood targets the cells that fuel the growth of tumours.

Broccoli contains high levels of sulforaphane which can kill these cancer stem cells and prevent the disease from developing, or spreading when it is established.

U.S. scientists at the University of Michigan Comprehensive Cancer Centre completed successful laboratory tests on mice and cell cultures.

Study author Professor Duxin Sun said: 'Sulforaphane has been studied previously for its effects on cancer, but this study shows that its benefit is in inhibiting the breast cancer stem cells.

'This new insight suggests the potential of sulforaphane or broccoli extract to prevent or treat cancer by targeting the critical cancer stem cells.'

A report on the findings is published in the Clinical Cancer Research journal.

Around 46,000 cases of breast cancer are diagnosed each year in Britain, with 12,000 dying from the disease. Current chemotherapy regimes do not work against cancer stem cells, which is why the disease recurs and spreads, say the researchers.

They believe that eliminating the cancer stem cells is critical to controlling the growth of tumours.

In the study, researchers took mice with breast cancer and injected varying concentrations of sulforaphane from the broccoli extract.

They then used several established methods to assess the number of cancer stem cells in the tumours.

These measures showed a marked drop in the cancer stem cell population after treatment with sulforaphane, with little effect on the normal cells. Furthermore, cancer cells from mice treated with the chemical were unable to generate new tumours.

The researchers then tested the compound on human breast cancer cell cultures in the lab, finding a similar fall in the number of cancer stem cells.

However, they warned that the concentrations used in the study were higher than those found in broccoli.

Because their work has not been tested in patients, they advise people against adding sulforaphane supplements to their diet in anticipation that it might prevent or treat cancer.

They are currently developing their own method to extract and preserve the chemical and will then carry out a clinical trial to test the process.

The vegetable's characteristically bitter taste means it is disliked by many - including former U.S. president George W. Bush.

But its health effects are widely recognised, with studies showing that a chemical in the vegetable boosts DNA repair in cells.

Other evidence suggests it keeps arteries healthy and may reverse the damage caused by diabetes to heart blood vessels.

It is high in vitamin C and fibre, and one stalk can provide nearly twice the recommended daily intake of vitamin K for an adult.

This information was in print at least twenty years ago. But why, if medical ppl know the values of certain veges, do they shovel us full of chemicals when we get cancer?

- J.B., Australia, 4/5/2010 16:51

Some 'chemicals' in a range of medicines have been derived from plants - fruits, flowers and vegetables.

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Have been eating raw broccoli ever since being diagnosed with stage 3 colon cancer was given given only 50% survival rate definately works as that was eleven years ago.

- RW, CO DURHAM ENGLAND, 4/5/2010 15:10

Same with a friend of mine. He also eats a lot of tinned tomatoes and tomato ketchup to benefit from the lycopene. This has been going on for about ten years and he remains fit and active.

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Dave K, whats with you? the DM are reporting something that is known; that cruciferous vegetables MAY have a stabilising effect on certain cancers...

.........(info not reproduced due to lack of space, sorry, Northern Lad).....

... its possible to discover more, the DM only brought it to your attention

- Northern Lad, Up North Pet


Where the DM goes wrong is to present information in a sensationalised fashion and very often with half of the facts missing. As has been highlighted by another comment, the place for some research papers is in the specialised journals of the discipline until such time as more is known on the subject and a practical and realistic form of treatment is available. Very few DM readers are sufficiently scientifically literate to enable them to treat these articles with the balance they demand.

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I agree with you Lisa. They inject so many hormones into chicken and turkey it's no wonder people get sick. As for fermented meats (ham, salami, etc), those are quite possibly some of the worst foods there are. Not only is it nothing but offal, but it's completely uncooked and is infested with e-coli bacteria. This way of preserving meats was used by PEASANTS in the middle ages for goodness sake! Why haven't we moved on?

- Yasmin, Boston, USA, 4/5/2010 21:30

It is possible to buy chicken and turkey without hormone additions Yasmin. This poultry is more expensive but I prefer to eat it less often but feel safe in the knowledge that no hormones have been added. I'm not clear about the problem in eating foods used by peasants per se. Porridge, for example, was originally a 'peasant' food yet it is one of the most healthy foods to eat. I think it is more about making informed choices on a variety of foods which you enjoy.

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A warning, anyone on Warfarin should not eat broccoli, vitamin K in the broccoli inter fears with the warfarin.

- big jannie, birkenhead merseyside, 04/5/2010 20:35

I knew this was true of spinach, but I hadn't realised caution should be exercised with broccoli too.

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